Guidance on platelet transfusion for patients with hypoproliferative thrombocytopenia.
Identifieur interne : 000482 ( Main/Exploration ); précédent : 000481; suivant : 000483Guidance on platelet transfusion for patients with hypoproliferative thrombocytopenia.
Auteurs : Susan Nahirniak [Canada] ; Sherrill J. Slichter [États-Unis] ; Susano Tanael [Canada] ; Paolo Rebulla [Italie] ; Katerina Pavenski [Canada] ; Ralph Vassallo [États-Unis] ; Mark Fung [États-Unis] ; Rene Duquesnoy [États-Unis] ; Chee-Loong Saw [Canada] ; Simon Stanworth [Royaume-Uni] ; Alan Tinmouth [Canada] ; Heather Hume [Canada] ; Arjuna Ponnampalam [Canada] ; Catherine Moltzan [Canada] ; Brian Berry [Canada] ; Nadine Shehata [Canada]Source :
- Transfusion medicine reviews [ 1532-9496 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- standards : Transfusion Medicine.
- Humans, Practice Guidelines as Topic.
Abstract
Patients with hypoproliferative thrombocytopenia are at an increased risk for hemorrhage and alloimmunization to platelets. Updated guidance for optimizing platelet transfusion therapy is needed as data from recent pivotal trials have the potential to change practice. This guideline, developed by a large international panel using a systematic search strategy and standardized methods to develop recommendations, incorporates recent trials not available when previous guidelines were developed. We found that prophylactic platelet transfusion for platelet counts less than or equal to 10 × 10(9)/L is the optimal approach to decrease the risk of hemorrhage for patients requiring chemotherapy or undergoing allogeneic or autologous transplantation. A low dose of platelets (1.41 × 10(11)/m2) is hemostatically as effective as higher dose of platelets but requires more frequent platelet transfusions suggesting that low-dose platelets may be used in hospitalized patients. For outpatients, a median dose (2.4 × 10(11)/m2) may be more cost-effective to prevent clinic visits only to receive a transfusion. In terms of platelet products, whole blood-derived platelet concentrates can be used interchangeably with apheresis platelets, and ABO-compatible platelet should be given to improve platelet increments and decrease the rate of refractoriness to platelet transfusion. For RhD-negative female children or women of child-bearing potential who have received RhD-positive platelets, Rh immunoglobulin should probably be given to prevent immunization to the RhD antigen. Providing platelet support for the alloimmunized refractory patients with ABO-matched and HLA-selected or crossmatched products is of some benefit, yet the degree of benefit needs to be assessed in the era of leukoreduction.
DOI: 10.1016/j.tmrv.2014.11.004
PubMed: 25537844
Affiliations:
- Canada, Italie, Royaume-Uni, États-Unis
- Angleterre, Lombardie, Manitoba, Ontario, Oxfordshire, Pennsylvanie, Québec, Vermont, Washington (État)
- Milan, Montréal, Oxford, Toronto, Winnipeg
- Université de Toronto, Université du Manitoba
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Le document en format XML
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Medicine and Pathology, University of Alberta and Alberta Health Services, Edmonton, Canada. Electronic address: Susan.Nahirniak@albertahealthservices.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, University of Alberta and Alberta Health Services, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Slichter, Sherrill J" sort="Slichter, Sherrill J" uniqKey="Slichter S" first="Sherrill J" last="Slichter">Sherrill J. Slichter</name><affiliation wicri:level="2"><nlm:affiliation>Puget Sound Blood Centre and University of Washington School of Medicine, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Puget Sound Blood Centre and University of Washington School of Medicine, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Tanael, Susano" sort="Tanael, Susano" uniqKey="Tanael S" first="Susano" last="Tanael">Susano Tanael</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Blood Services, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Blood Services, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Rebulla, Paolo" sort="Rebulla, Paolo" uniqKey="Rebulla P" first="Paolo" last="Rebulla">Paolo Rebulla</name><affiliation wicri:level="3"><nlm:affiliation>Centre of Transfusion Medicine, Cellular Therapy and Cryobiology, Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centre of Transfusion Medicine, Cellular Therapy and Cryobiology, Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pavenski, Katerina" sort="Pavenski, Katerina" uniqKey="Pavenski K" first="Katerina" last="Pavenski">Katerina Pavenski</name><affiliation wicri:level="4"><nlm:affiliation>Department of Laboratory Medicine, St Michael's Hospital, Department of Laboratory Medicine and Pathobiology, and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine, St Michael's Hospital, Department of Laboratory Medicine and Pathobiology, and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Vassallo, Ralph" sort="Vassallo, Ralph" uniqKey="Vassallo R" first="Ralph" last="Vassallo">Ralph Vassallo</name><affiliation wicri:level="2"><nlm:affiliation>American Red Cross Blood Services, Penn-Jersey Region, Philadelphia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>American Red Cross Blood Services, Penn-Jersey Region, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Fung, Mark" sort="Fung, Mark" uniqKey="Fung M" first="Mark" last="Fung">Mark Fung</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of Vermont and Fletcher Allen Health Care, Burlington, VT.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, University of Vermont and Fletcher Allen Health Care, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Duquesnoy, Rene" sort="Duquesnoy, Rene" uniqKey="Duquesnoy R" first="Rene" last="Duquesnoy">Rene Duquesnoy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Pittsburgh Medical Centre, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology, University of Pittsburgh Medical Centre, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Saw, Chee Loong" sort="Saw, Chee Loong" uniqKey="Saw C" first="Chee-Loong" last="Saw">Chee-Loong Saw</name><affiliation wicri:level="3"><nlm:affiliation>HLA Laboratory, Hematology Division, McGill University Health Centre, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>HLA Laboratory, Hematology Division, McGill University Health Centre, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Stanworth, Simon" sort="Stanworth, Simon" uniqKey="Stanworth S" first="Simon" last="Stanworth">Simon Stanworth</name><affiliation wicri:level="3"><nlm:affiliation>National Health Service Blood and Transplant, Oxford University Hospitals Trust, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Oxford University Hospitals Trust, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Tinmouth, Alan" sort="Tinmouth, Alan" uniqKey="Tinmouth A" first="Alan" last="Tinmouth">Alan Tinmouth</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Ottawa Hospital and University of Ottawa, and the Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Ottawa Hospital and University of Ottawa, and the Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Hume, Heather" sort="Hume, Heather" uniqKey="Hume H" first="Heather" last="Hume">Heather Hume</name><affiliation wicri:level="3"><nlm:affiliation>Département de Pédiatrie, Universtié de Montréal, CHU Sainte-Justine Montréal, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Département de Pédiatrie, Universtié de Montréal, CHU Sainte-Justine Montréal, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Ponnampalam, Arjuna" sort="Ponnampalam, Arjuna" uniqKey="Ponnampalam A" first="Arjuna" last="Ponnampalam">Arjuna Ponnampalam</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Moltzan, Catherine" sort="Moltzan, Catherine" uniqKey="Moltzan C" first="Catherine" last="Moltzan">Catherine Moltzan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Internal Medicine, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Berry, Brian" sort="Berry, Brian" uniqKey="Berry B" first="Brian" last="Berry">Brian Berry</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Sciences, University of Victoria, Victoria, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Medical Sciences, University of Victoria, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Shehata, Nadine" sort="Shehata, Nadine" uniqKey="Shehata N" first="Nadine" last="Shehata">Nadine Shehata</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Medicine and Obstetric Medicine, Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Medicine and Obstetric Medicine, Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></analytic><series><title level="j">Transfusion medicine reviews</title><idno type="eISSN">1532-9496</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Practice Guidelines as Topic</term><term>Transfusion Medicine (standards)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Médecine transfusionnelle (normes)</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Médecine transfusionnelle</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Transfusion Medicine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Practice Guidelines as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with hypoproliferative thrombocytopenia are at an increased risk for hemorrhage and alloimmunization to platelets. Updated guidance for optimizing platelet transfusion therapy is needed as data from recent pivotal trials have the potential to change practice. This guideline, developed by a large international panel using a systematic search strategy and standardized methods to develop recommendations, incorporates recent trials not available when previous guidelines were developed. We found that prophylactic platelet transfusion for platelet counts less than or equal to 10 × 10(9)/L is the optimal approach to decrease the risk of hemorrhage for patients requiring chemotherapy or undergoing allogeneic or autologous transplantation. A low dose of platelets (1.41 × 10(11)/m2) is hemostatically as effective as higher dose of platelets but requires more frequent platelet transfusions suggesting that low-dose platelets may be used in hospitalized patients. For outpatients, a median dose (2.4 × 10(11)/m2) may be more cost-effective to prevent clinic visits only to receive a transfusion. In terms of platelet products, whole blood-derived platelet concentrates can be used interchangeably with apheresis platelets, and ABO-compatible platelet should be given to improve platelet increments and decrease the rate of refractoriness to platelet transfusion. For RhD-negative female children or women of child-bearing potential who have received RhD-positive platelets, Rh immunoglobulin should probably be given to prevent immunization to the RhD antigen. Providing platelet support for the alloimmunized refractory patients with ABO-matched and HLA-selected or crossmatched products is of some benefit, yet the degree of benefit needs to be assessed in the era of leukoreduction.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Lombardie</li><li>Manitoba</li><li>Ontario</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Québec</li><li>Vermont</li><li>Washington (État)</li></region><settlement><li>Milan</li><li>Montréal</li><li>Oxford</li><li>Toronto</li><li>Winnipeg</li></settlement><orgName><li>Université de Toronto</li><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Nahirniak, Susan" sort="Nahirniak, Susan" uniqKey="Nahirniak S" first="Susan" last="Nahirniak">Susan Nahirniak</name></noRegion><name sortKey="Berry, Brian" sort="Berry, Brian" uniqKey="Berry B" first="Brian" last="Berry">Brian Berry</name><name sortKey="Hume, Heather" sort="Hume, Heather" uniqKey="Hume H" first="Heather" last="Hume">Heather Hume</name><name sortKey="Moltzan, Catherine" sort="Moltzan, Catherine" uniqKey="Moltzan C" first="Catherine" last="Moltzan">Catherine Moltzan</name><name sortKey="Pavenski, Katerina" sort="Pavenski, Katerina" uniqKey="Pavenski K" first="Katerina" last="Pavenski">Katerina Pavenski</name><name sortKey="Ponnampalam, Arjuna" sort="Ponnampalam, Arjuna" uniqKey="Ponnampalam A" first="Arjuna" last="Ponnampalam">Arjuna Ponnampalam</name><name sortKey="Saw, Chee Loong" sort="Saw, Chee Loong" uniqKey="Saw C" first="Chee-Loong" last="Saw">Chee-Loong Saw</name><name sortKey="Shehata, Nadine" sort="Shehata, Nadine" uniqKey="Shehata N" first="Nadine" last="Shehata">Nadine Shehata</name><name sortKey="Tanael, Susano" sort="Tanael, Susano" uniqKey="Tanael S" first="Susano" last="Tanael">Susano Tanael</name><name sortKey="Tinmouth, Alan" sort="Tinmouth, Alan" uniqKey="Tinmouth A" first="Alan" last="Tinmouth">Alan Tinmouth</name></country><country name="États-Unis"><region name="Washington (État)"><name sortKey="Slichter, Sherrill J" sort="Slichter, Sherrill J" uniqKey="Slichter S" first="Sherrill J" last="Slichter">Sherrill J. Slichter</name></region><name sortKey="Duquesnoy, Rene" sort="Duquesnoy, Rene" uniqKey="Duquesnoy R" first="Rene" last="Duquesnoy">Rene Duquesnoy</name><name sortKey="Fung, Mark" sort="Fung, Mark" uniqKey="Fung M" first="Mark" last="Fung">Mark Fung</name><name sortKey="Vassallo, Ralph" sort="Vassallo, Ralph" uniqKey="Vassallo R" first="Ralph" last="Vassallo">Ralph Vassallo</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Rebulla, Paolo" sort="Rebulla, Paolo" uniqKey="Rebulla P" first="Paolo" last="Rebulla">Paolo Rebulla</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Stanworth, Simon" sort="Stanworth, Simon" uniqKey="Stanworth S" first="Simon" last="Stanworth">Simon Stanworth</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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